Applying Pharmacogenomics In Therapeutics

Description

Edited by Feng Xiaodong; Edited by Xie Hong-Guang

Short /annotation:
This book covers the principles, practice, and potential of pharmacogenomics and personalized medicine, employing patient case profiles to illustrate key concepts and clinical applications. Featuring contributions from well-established pharmacologists/scientists, this authoritative text depicts the use of genetic biomarkers in drug discovery and

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Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare—i.e., personalized medicine.

Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text:

• Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care
• Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services
• Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases
• Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics

Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Table of contents:

Concepts in Pharmacogenomics and Personalized Medicine. Principles of Pharmacogenetic Biotechnology and Testing in Clinical Practice. Essential Pharmacogenomic Biomarkers in Clinical Practice. Applying Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics and Laboratory Medicine. Clinical Applications of Pharmacogenomics in Cancer Therapy.
Clinical Applications of Pharmacogenomics in Drug Therapy of Cardiovascular Diseases. Clinical Applications of Pharmacogenomics in Drug Therapy of Neurologic and Psychiatric Disorders. Applying Pharmacogenomics in the Therapeutics of Pulmonary Diseases. Pharmacogenomics and Alternative Medicine: Merge of Future and Tradition. Pharmacoeconogenomics: A Good Marriage of Pharmacoeconomics and Pharmacogenomics.

Review quote:

The book exemplifies clinical cases of genetic variants in several diseases, defining genetic determinants for drug response and thoroughly describes the applications and therapy in clinical practice. Finally, the authors connect pharmacogenomics with the generation of cost-effectiveness treatments.

Applying Pharmacogenomics in Therapeutics is intended for graduate, medical school courses. or healthcare professionals with a deep focus on genomics, pharmacy, pharmacology, and clinical care practice. Healthcare providers and research scientists would benefit from this text as a reference tool of the recent advances in this field. This text is well written and provides useful examples, tables and clinical cases to better understand and practice the concepts being described. Each chapter begins with a short list of key concepts, an introduction to the topic of the chapter, and concludes with a summary and study questions to practice. The book facilitates an extensive nu